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Pregnancy: Acyclovir has not been shown to be teratogenic in standard test following administration in animals. However, there are no adequate and controlled studies to date using Acyclovir in pregnant women, and the drug should be used during pregnancy only when the potential benefits justify the possible risks to the fetus.
Lactation: Although it is not known whether Acyclovir is distributed into milk following topical application. Therefore, Acyclovir cream should be used with caution in nursing women. Women who have active herpetic lesions near or on the breast should avoid nursing.
